Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studies.

ABSTRACT: Type IV secretion systems are possibly the most versatile protein transport systems in gram-negative bacteria, with substrates ranging from small proteins to large nucleoprotein complexes. In many cases, such as the cag pathogenicity island of Helicobacter pylori, genes encoding components of a type IV secretion system have been identified due to their sequence similarities to prototypical systems such as the VirB system of Agrobacterium tumefaciens. The Cag type IV secretion system contains at least 14 essential apparatus components and several substrate translocation and auxiliary factors, but the functions of most components cannot be inferred from their sequences due to the lack of similarities. In this study, we have performed a comprehensive sequence analysis of all essential or auxi

SUBMITTER: Kutter S 

PROVIDER: S-EPMC2258873 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature