SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression.

ABSTRACT: The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.

SUBMITTER: Cheung AL 

PROVIDER: S-EPMC2258893 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature