The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates.

ABSTRACT: Legionella pneumophila has been shown to utilize the icm/dot type IV secretion system for pathogenesis. This system was shown to be composed of icm/dot complex components and accessory proteins, as well as a large number of translocated substrates. Bioinformatic analysis of the regulatory regions of all the genes revealed that several icm/dot genes, as well as two genes encoding icm/dot translocated substrates, contain the conserved CpxR regulatory element, a regulator that has been shown previously to control the expression of the icmR gene. An experimental analysis, which included a comparison of gene expression in a L. pneumophila wild-type strain and gene expression in a cpxR deletion mutant, construction of mutants with mutations in the CpxR conserved regulatory elements, controlled e

SUBMITTER: Altman E 

PROVIDER: S-EPMC2258895 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature