Complex aetiology of an apparently Mendelian form of mental retardation.

ABSTRACT:

Background

Mental Retardation is a common heterogeneous neurodevelopment condition, which causes are still largely elusive. It has been suggested that half of the phenotypic variation of intelligence is explained by genetic variation. And genetic or inherited factors indeed account for most of the cases of mental retardation with an identifiable cause. However, only a few autosomal genes have been mapped and identified to date. In this report, the genetic causes for an apparently recessive form of mental retardation, in a large nordern swedish pedigree, are investigated.

Methods

After extensive evaluation of the patients, which ruled out recognizable patterns of malformation and excluded known causes of MR, a comprehensive genome-wide linkage analysis, with 500 microsatellit

SUBMITTER: Beleza-Meireles A 

PROVIDER: S-EPMC2259315 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature