Annotation and analysis of a large cuticular protein family with the R&R Consensus in Anopheles gambiae.

ABSTRACT:

Background

The most abundant family of insect cuticular proteins, the CPR family, is recognized by the R&R Consensus, a domain of about 64 amino acids that binds to chitin and is present throughout arthropods. Several species have now been shown to have more than 100 CPR genes, inviting speculation as to the functional importance of this large number and diversity.

Results

We have identified 156 genes in Anopheles gambiae that code for putative cuticular proteins in this CPR family, over 1% of the total number of predicted genes in this species. Annotation was verified using several criteria including identification of TATA boxes, INRs, and DPEs plus support from proteomic and gene expression analyses. Two previously recognized CPR classes, RR-1 and RR-2, form separate, well

SUBMITTER: Cornman RS 

PROVIDER: S-EPMC2259329 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature