Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice.

ABSTRACT:

Background

Pancreatic carcinoma usually is a fatal disease with no cure, mainly due to its invasion and metastasis prior to diagnosis. We analyzed the gene expression profiles of paired primary pancreatic tumors and metastatic lesions from Ela-c-myc transgenic mice in order to identify genes that may be involved in the pancreatic cancer progression. Differentially expressed selected genes were verified by semi-quantitative and quantitative RT-PCR. To further evaluate the relevance of some of the selected differentially expressed genes, we investigated their expression pattern in human pancreatic cancer cell lines with high and low metastatic potentials.

Results

Data indicate that genes involved in posttranscriptional regulation were a major functional category of upregulated

SUBMITTER: Thakur A 

PROVIDER: S-EPMC2259361 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature