Structural damage to the corticospinal tract correlates with bilateral sensorimotor cortex reorganization in stroke patients.

ABSTRACT: Damage to the corticospinal tract (CST) in stroke patients has been associated with functional reorganization in the ipsilesional and contralesional sensorimotor cortices. However, it is unknown whether a quantitative relationship exists between the extent of structural damage to the CST and functional reorganization in stroke patients. The purpose of the current study was to examine the relationship between structural CST damage and motor task-related cortical activity in chronic hemiparetic stroke patients. In 10 chronic hemiparetic stroke patients with heterogeneous lesions, CST damage was quantified using conventional structural magnetic resonance imaging and tractography based on diffusion tensor imaging. Cortical activity was measured using functional magnetic resonance imaging durin

SUBMITTER: Schaechter JD 

PROVIDER: S-EPMC2259387 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature