Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution.

ABSTRACT:

Background

Glycolipid transfer protein is the prototypical and founding member of the new GLTP superfamily distinguished by a novel conformational fold and glycolipid binding motif. The present investigation provides the first insights into the organization, transcriptional status, phylogenetic/evolutionary relationships of GLTP genes.

Results

In human cells, single-copy GLTP genes were found in chromosomes 11 and 12. The gene at locus 11p15.1 exhibited several features of a potentially active retrogene, including a highly homologous (approximately 94%), full-length coding sequence containing all key amino acid residues involved in glycolipid liganding. To establish the transcriptional activity of each human GLTP gene, in silico EST evaluations, RT-PCR amplifications of GLTP

SUBMITTER: Zou X 

PROVIDER: S-EPMC2262070 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature