Activation of counter-regulatory mechanisms in a rat renal acute rejection model.

ABSTRACT:

Background

Microarray analysis provides a powerful approach to identify gene expression alterations following transplantation. In patients the heterogeneity of graft specimens, co-morbidity, co-medications and the challenges in sample collection and preparation complicate conclusions regarding the underlying mechanisms of graft injury, rejection and immune regulation.

Results

We used a rat kidney transplantation model with strict transplant and sample preparation procedures to analyze genome wide changes in gene expression four days after syngeneic and allogeneic transplantation. Both interventions were associated with substantial changes in gene expression. After allogeneic transplantation, genes and pathways related to transport and metabolism were predominantly down-regul

SUBMITTER: Edemir B 

PROVIDER: S-EPMC2262896 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature