The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae.

ABSTRACT:

Background

The corn smut fungus Ustilago maydis is a well-established model system for molecular phytopathology. In addition, it recently became evident that U. maydis and humans share proteins and cellular processes that are not found in the standard fungal model Saccharomyces cerevisiae. This prompted us to do a comparative analysis of the predicted proteome of U. maydis, S. cerevisiae and humans.

Results

At a cut off at 20% identity over protein length, all three organisms share 1738 proteins, whereas both fungi share only 541 conserved proteins. Despite the evolutionary distance between U. maydis and humans, 777 proteins were shared. When applying a more stringent criterion (> or = 20% identity with a homologue in one organism over at least 50 amino acids and > or = 10%

SUBMITTER: Munsterkotter M 

PROVIDER: S-EPMC2262911 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature