Dissecting the logical types of network control in gene expression profiles.

ABSTRACT:

Background

In the bacterium Escherichia coli the transcriptional regulation of gene expression involves both dedicated regulators binding specific DNA sites with high affinity and also global regulators - abundant DNA architectural proteins of the bacterial nucleoid binding multiple sites with a wide range of affinities and thus modulating the superhelical density of DNA. The first form of transcriptional regulation is predominantly pairwise and specific, representing digitial control, while the second form is (in strength and distribution) continuous, representing analog control.

Results

Here we look at the properties of effective networks derived from significant gene expression changes under variation of the two forms of control and find that upon limitations of one type

SUBMITTER: Marr C 

PROVIDER: S-EPMC2263018 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature