Gene expression patterns within cell lines are predictive of chemosensitivity.

ABSTRACT:

Background

The NCI has undertaken a twenty-year project to characterize compound sensitivity patterns in a selected set of sixty tumor derived cell lines. Previous studies have explored the relationship between compound sensitivity patterns to gene expression, protein expression, and DNA copy number for these same cell lines. A strong correlation between the pattern of expression of a biomarker and sensitivity to a compound could suggest a clinically interesting biological relationship between the two.

Results

We isolated RNA's and measured expression of 40000 genes using cDNA microarrays from the fifty-nine publicly available cell lines. Analysis of this data set in comparison with published gene expression data sets demonstrates a high degree of reproducibility in expressi

SUBMITTER: Ring BZ 

PROVIDER: S-EPMC2263043 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature