Serial Analysis of Gene Expression in Plasmodium berghei salivary gland sporozoites.

ABSTRACT:

Background

The invasion of Anopheles salivary glands by Plasmodium sporozoites is an essential step for transmission of the parasite to the vertebrate host. Salivary gland sporozoites undergo a developmental programme to express genes required for their journey from the site of the mosquito bite to the liver and subsequent invasion of, and development within, hepatocytes. A Serial Analysis of Gene Expression was performed on Anopheles gambiae salivary glands infected or not with Plasmodium berghei and we report here the analysis of the Plasmodium sporozoite transcriptome.

Results

Annotation of 530 tag sequences homologous to Plasmodium berghei genomic sequences identified 123 genes expressed in salivary gland sporozoites and these genes were classified according to their tra

SUBMITTER: Rosinski-Chupin I 

PROVIDER: S-EPMC2263065 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature