Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors.

ABSTRACT:

Background

Gene transcription patterns associated with activation of oncogenes Myc, c-Src, beta-catenin, E2F3, H-Ras, HER2, EGFR, MEK, Raf, MAPK, Akt, and cyclin D1, as well as of the cell cycle and of androgen signaling have been generated in previous studies using experimental models. It was not clear whether genes in these "oncogenic signatures" would show coordinate expression patterns in human prostate tumors, particularly as most of the signatures were derived from cell types other than prostate.

Principal findings

The above oncogenic pathway signatures were examined in four different gene expression profile datasets of human prostate tumors (representing approximately 250 patients in all), using both Q1-Q2 and one-sided Fisher's exact enrichment analysis methods. A si

SUBMITTER: Creighton CJ 

PROVIDER: S-EPMC2263127 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature