Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis.

ABSTRACT:

Background

Glutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined.

Objectives

This study was designed to investigate whether sequence variations in the GSTP1 coding and promoter regions are associated with asthma and wheezing outcomes and to determine whether variants affect susceptibility to maternal smoking.

Methods

Four haplotype tagging SNPs were selected that accounted for 83% of the common haplotypic variation in GSTP1. The associations of GSTP1 variants with asthma and wheezing were assessed among white children in the Children's Health Study (CHS).

Results

The Ile105Val allele and a SNP in the upstream pro

SUBMITTER: Li YF 

PROVIDER: S-EPMC2265034 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature