Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease.

ABSTRACT: Substantial evidence from epidemiological, pathological, and clinical reports suggests that vascular factors are critical in the pathogenesis of Alzheimer's disease (AD), and changes in blood flow are currently the most reliable indicators of the disease. We previously reported that older APP23 transgenic (tg) mice have significant blood flow alterations correlated with structural modifications of blood vessels. For the present study, our objective was to analyze the age-dependent morphological and architectural changes of the cerebral vasculature of APP23 tg mice. To visualize the 3D arrangement of the entire brain vasculature, we used vascular corrosion casts. Already at young ages, when typically parenchymal amyloid plaques are not yet present, APP23 tg mice had significant alterations,

SUBMITTER: Meyer EP 

PROVIDER: S-EPMC2265182 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature