Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis.

ABSTRACT: Histone deacetylases (HDACs) execute biological regulation through post-translational modification of chromatin and other cellular substrates. In humans, there are eleven HDACs, organized into three distinct subfamilies. This large number of HDACs raises questions about functional overlap and division of labor among paralogs. In vivo roles are simpler to address in Drosophila, where there are only five HDAC family members and only two are implicated in transcriptional control. Of these two, HDAC1 has been characterized genetically, but its most closely related paralog, HDAC3, has not. Here we describe the isolation and phenotypic characterization of hdac3 mutations. We find that both hdac3 and hdac1 mutations are dominant suppressors of position effect variegation, suggesting functional ov

SUBMITTER: Zhu CC 

PROVIDER: S-EPMC2265479 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature