Early antibody response against Mycobacterium avium subspecies paratuberculosis antigens in subclinical cattle.

ABSTRACT:

Background

Our laboratories have previously reported on the experimental infection of cattle with Mycobacterium avium subsp paratuberculosis (M. paratuberculosis) using an intratonsillar infection model. In addition, we have recently developed a partial protein array representing 92 M. paratuberculosis coding sequences. These combined tools have enabled a unique look at the temporal analysis of M. paratuberculosis antigens within the native host. The primary objective of this study was to identify M. paratuberculosis antigens detected by cattle early during infection. A secondary objective was to evaluate the humoral immune response in cattle during the initial year of infection.

Results

Sera from two experimentally infected cattle, taken pre-inoculation and at day 70, 194 a

SUBMITTER: Bannantine JP 

PROVIDER: S-EPMC2265687 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature