Regulation of hepatitis C virion production via phosphorylation of the NS5A protein.

ABSTRACT: Hepatitis C virus (HCV) is a significant pathogen, infecting some 170 million people worldwide. Persistent virus infection often leads to cirrhosis and liver cancer. In the infected cell many RNA directed processes must occur to maintain and spread infection. Viral genomic RNA is constantly replicating, serving as template for translation, and being packaged into new virus particles; processes that cannot occur simultaneously. Little is known about the regulation of these events. The viral NS5A phosphoprotein has been proposed as a regulator of events in the HCV life cycle for years, but the details have remained enigmatic. NS5A is a three-domain protein and the requirement of domains I and II for RNA replication is well documented. NS5A domain III is not required for RNA replication, and

SUBMITTER: Tellinghuisen TL 

PROVIDER: S-EPMC2265800 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature