Structural and functional diversification in the teleost S100 family of calcium-binding proteins.

ABSTRACT:

Background

Among the EF-Hand calcium-binding proteins the subgroup of S100 proteins constitute a large family with numerous and diverse functions in calcium-mediated signaling. The evolutionary origin of this family is still uncertain and most studies have examined mammalian family members.

Results

We have performed an extensive search in several teleost genomes to establish the s100 gene family in fish. We report that the teleost S100 repertoire comprises fourteen different subfamilies which show remarkable similarity across six divergent teleost species. Individual species feature distinctive subsets of thirteen to fourteen genes that result from local gene duplications and gene losses. Eight of the fourteen S100 subfamilies are unique for teleosts, while six are shared wi

SUBMITTER: Kraemer AM 

PROVIDER: S-EPMC2266712 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature