Hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions.

ABSTRACT:

Background

Hsp70 chaperones are required for key cellular processes and response to environmental changes and survival but they have not been fully characterized yet. The human hsp70-gene family has an unknown number of members (eleven counted over ten years ago); some have been described but the information is incomplete and inconsistent. A coherent body of knowledge encompassing all family components that would facilitate their study individually and as a group is lacking. Nowadays, the study of chaperone genes benefits from the availability of genome sequences and a new protocol, chaperonomics, which we applied to elucidate the human hsp70 family.

Results

We identified 47 hsp70 sequences, 17 genes and 30 pseudogenes. The genes distributed into seven evolutionarily distinc

SUBMITTER: Brocchieri L 

PROVIDER: S-EPMC2266713 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature