The complete genome sequence of a Crimean-Congo hemorrhagic fever virus isolated from an endemic region in Kosovo.

ABSTRACT: The Balkan region and Kosovo in particular, is a well-known Crimean-Congo hemorrhagic fever (CCHF) endemic region, with frequent epidemic outbreaks and sporadic cases occurring with a hospitalized case fatality of approximately 30%. Recent analysis of complete genome sequences of diverse CCHF virus strains showed that the genome plasticity of the virus is surprisingly high for an arthropod-borne virus. High levels of nucleotide and amino acid differences, frequent RNA segment reassortment and even RNA recombination have been recently described. This diversity illustrates the need to determine the complete genome sequence of CCHF virus representatives of all geographically distinct endemic areas, particularly in light of the high pathogenicity of the virus and its listing as a potential bio

SUBMITTER: Duh D 

PROVIDER: S-EPMC2266736 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature