Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy.

ABSTRACT:

Context

The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy.

Objective

The objective of the study was to investigate the temporal relationships among changes in adipogenic gene expression in sc adipose tissue and changes in body fat distribution and metabolic complications in HIV-infected subjects on antiretroviral therapy.

Design

This was a prospective longitudinal study.

Setting

The study was conducted at HIV clinics in Seattle, Washington.

Participants

The study population included 31 HIV-infected and 12 control subjects.

Interventions

Subjects were followed up for 12 month

SUBMITTER: Kratz M 

PROVIDER: S-EPMC2266944 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature