Bone mineral density changes during the menopause transition in a multiethnic cohort of women.

ABSTRACT:

Context

Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood.

Objective

Our objective was to assess rates of bone loss at each stage of the transition and examine major factors that modify those rates.

Design, setting, and participants

We conducted a longitudinal cohort study of 1902 African-American, Caucasian, Chinese, or Japanese women participating in The Study of Women's Health Across the Nation. Women were pre- or early perimenopausal at baseline.

Outcome measure

We assessed bone mineral density (BMD) of the lumbar spine and total hip across a maximum of six annual visits.

Results

There was little change in BMD during the pre- or early perimenopause. BMD declined subs

SUBMITTER: Finkelstein JS 

PROVIDER: S-EPMC2266953 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature