Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

ABSTRACT:

Context

Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood.

Objective

Our objective was to identify predictive genetic polymorphisms and other determinants of ovulatory response.

Design

This was a substudy of a multicenter randomized clinical trial.

Setting

This study was performed at academic medical centers and their affiliates.

Participants

A total of 312 women with PCOS were included in the study.

Main outcome measures

Historical, biometric, biochemical, and genetic parameters were performed.

Results

We found that the C allele of a single nucleotide polymorphism in the STK11 g

SUBMITTER: Legro RS 

PROVIDER: S-EPMC2266955 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature