Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.

ABSTRACT:

Background

Pregnancy-associated malaria (PAM) causing maternal anemia and low birth weight is among the multiple manifestations of Plasmodium falciparum malaria. Infected erythrocytes (iEs) can acquire various adhesive properties that mediate the clinical severity of malaria. Recent advances on the molecular basis of virulence and immune evasion have helped identify var2csa as a PAM-specific var gene.

Methodology/principal findings

The present study presents a genome-wide microarray transcript analysis of 18 P. falciparum parasite isolates freshly collected from the placenta. The proportion of PAM over-expressed genes located in subtelomeric regions as well as that of PAM over-expressed genes predicted to be exported were higher than expected compared to the whole genome. Th

SUBMITTER: Tuikue Ndam N 

PROVIDER: S-EPMC2267001 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature