Meta-analysis of BRCA1 and BRCA2 penetrance.

ABSTRACT:

Purpose

Genetic counseling is now routinely offered to individuals at high risk of carrying a BRCA1 or BRCA2 mutation. Risk prediction provided by the counselor requires reliable estimates of the mutation penetrance. Such penetrance has been investigated by studies worldwide. The reported estimates vary. To facilitate clinical management and counseling of the at-risk population, we address this issue through a meta-analysis.

Methods

We conducted a literature search on PubMed and selected studies that had nonoverlapping patient data, contained genotyping information, used statistical methods that account for the ascertainment, and reported risks in a useable format. We subsequently combined the published estimates using the DerSimonian and Laird random effects modeling approa

SUBMITTER: Chen S 

PROVIDER: S-EPMC2267287 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature