An essential role for fibronectin extra type III domain A in pulmonary fibrosis.

ABSTRACT:

Rationale

Tissue fibrosis is considered a dysregulated wound-healing response. Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen.

Objectives

To investigate the role of EDA-containing fibronectin in lung fibrogenesis.

Methods

Primary lung fibroblasts from patients with idiopathic pulmonary fibrosis or from patients undergoing resection for lung cancer were assessed for EDA-containing fibronectin and alpha-smooth muscle actin (alpha-SMA) expression. Mice lacking the EDA domain of fibronectin and their wild-type littermates were challenged with the bleomycin model of lung fibrosis. Primary lung fibroblasts from these

SUBMITTER: Muro AF 

PROVIDER: S-EPMC2267338 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature