Eigengene networks for studying the relationships between co-expression modules.

ABSTRACT:

Background

There is evidence that genes and their protein products are organized into functional modules according to cellular processes and pathways. Gene co-expression networks have been used to describe the relationships between gene transcripts. Ample literature exists on how to detect biologically meaningful modules in networks but there is a need for methods that allow one to study the relationships between modules.

Results

We show that network methods can also be used to describe the relationships between co-expression modules and present the following methodology. First, we describe several methods for detecting modules that are shared by two or more networks (referred to as consensus modules). We represent the gene expression profiles of each module by an eigengene.

SUBMITTER: Langfelder P 

PROVIDER: S-EPMC2267703 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature