Isoform switching facilitates period control in the Neurospora crassa circadian clock.

ABSTRACT: A striking and defining feature of circadian clocks is the small variation in period over a physiological range of temperatures. This is referred to as temperature compensation, although recent work has suggested that the variation observed is a specific, adaptive control of period. Moreover, given that many biological rate constants have a Q(10) of around 2, it is remarkable that such clocks remain rhythmic under significant temperature changes. We introduce a new mathematical model for the Neurospora crassa circadian network incorporating experimental work showing that temperature alters the balance of translation between a short and long form of the FREQUENCY (FRQ) protein. This is used to discuss period control and functionality for the Neurospora system. The model reproduces a broad r

SUBMITTER: Akman OE 

PROVIDER: S-EPMC2267733 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature