Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression.

ABSTRACT: Biological networks are inherently modular, yet little is known about how modules are assembled to enable coordinated and complex functions. We used RNAi and time series, whole-genome microarray analyses to systematically perturb and characterize components of a Caenorhabditis elegans lineage-specific transcriptional regulatory network. These data are supported by selected reporter gene analyses and comprehensive yeast one-hybrid and promoter sequence analyses. Based on these results, we define and characterize two modules composed of muscle- and epidermal-specifying transcription factors that function together within a single cell lineage to robustly specify multiple cell types. The expression of these two modules, although positively regulated by a common factor, is reliably segregated a

SUBMITTER: Yanai I 

PROVIDER: S-EPMC2267734 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature