Episodic sexual transmission of HIV revealed by molecular phylodynamics.

ABSTRACT:

Background

The structure of sexual contact networks plays a key role in the epidemiology of sexually transmitted infections, and their reconstruction from interview data has provided valuable insights into the spread of infection. For HIV, the long period of infectivity has made the interpretation of contact networks more difficult, and major discrepancies have been observed between the contact network and the transmission network revealed by viral phylogenetics. The high rate of HIV evolution in principle allows for detailed reconstruction of links between virus from different individuals, but often sampling has been too sparse to describe the structure of the transmission network. The aim of this study was to analyze a high-density sample of an HIV-infected population using recen

SUBMITTER: Lewis F 

PROVIDER: S-EPMC2267814 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature