Abnormal connections in the supraspinal bladder control network in women with urge urinary incontinence.

ABSTRACT: The regions of the supraspinal network that controls urinary bladder behavior are well known, but little is known about their interconnections. We tested the feasibility of using physiophysiological interaction to explore the effective connections of the network and to seek disease-related differences in connectivity. This was a secondary analysis of fMRI data obtained from women aged 26-85 years, 11 with urge urinary incontinence and 10 with normal bladder function. In each subject, fMRI BOLD images were obtained during a period with full bladder and strong bladder sensation (without detrusor overactivity) while repeatedly infusing and withdrawing a small amount of liquid in and out of the bladder. Regions of interest included right insula (RI) and anterior cingulate gyrus (ACG), both con

SUBMITTER: Tadic SD 

PROVIDER: S-EPMC2267872 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature