Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial.

ABSTRACT:

Objectives

To assess whether supplementation with antioxidants, folinic acid, or both improves the psychomotor and language development of children with Down's syndrome.

Design

Randomised controlled trial with two by two factorial design.

Setting

Children living in the Midlands, Greater London, and the south west of England.

Participants

156 infants aged under 7 months with trisomy 21.

Intervention

Daily oral supplementation with antioxidants (selenium 10 mug, zinc 5 mg, vitamin A 0.9 mg, vitamin E 100 mg, and vitamin C 50 mg), folinic acid (0.1 mg), antioxidants and folinic acid combined, or placebo.

Main outcome measures

Griffiths developmental quotient and an adapted MacArthur communicative development inventory 18 months after starting supplem

SUBMITTER: Ellis JM 

PROVIDER: S-EPMC2267988 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature