MEGF10 association with schizophrenia.

ABSTRACT:

Background

The 5q21-31 region has been implicated as harboring risk genes for schizophrenia in many linkage studies. In our previous report of stepwise fine mapping of this region, the MEGF10 gene was one of the genes showing consistent associations in our screening subsample. In this study, we carried out independent replication and expression studies of the MEGF10 gene.

Methods

Association studies with 8 SNPs in the MEGF10 gene were performed in the Irish case-control study of schizophrenia (ICCSS) sample (652 case and 617 control subjects). The expression of MEGF10 was also compared between healthy control subjects and schizophrenia patients using postmortem brain cDNA libraries.

Results

In the ICCSS sample, associations with the disease were found in the same risk

SUBMITTER: Chen X 

PROVIDER: S-EPMC2268016 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature