Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

ABSTRACT: The cytochromes P450 (CYPs) comprise a vast superfamily of enzymes found in virtually all life forms. In mammals, xenobiotic metabolizing CYPs provide crucial protection from the effects of exposure to a wide variety of chemicals, including environmental toxins and therapeutic drugs. Ideally, the information on the possible metabolism by CYPs required during drug development would be obtained from crystal structures of all the CYPs of interest. For some years only crystal structures of distantly related bacterial CYPs were available and homology modelling techniques were used to bridge the gap and produce structural models of human CYPs, and thereby obtain useful functional information. A significant step forward in the reliability of these models came seven years ago with the first crysta

SUBMITTER: Marechal JD 

PROVIDER: S-EPMC2268062 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature