Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning.

ABSTRACT: A neuroprotected state can be acquired by preconditioning brain with a stimulus that is subthreshold for damage (tolerance). Acquisition of tolerance involves coordinate, bi-directional changes to gene expression levels and the re-programmed phenotype is determined by the preconditioning stimulus. While best studied in ischemic brain there is evidence brief seizures can confer tolerance against prolonged seizures (status epilepticus). Presently, we developed a model of epileptic preconditioning in mice and used microarrays to gain insight into the transcriptional phenotype within the target hippocampus at the time tolerance had been acquired. Epileptic tolerance was induced by an episode of non-damaging seizures in adult C57Bl/6 mice using a systemic injection of kainic acid. Neuron and DN

SUBMITTER: Hatazaki S 

PROVIDER: S-EPMC2268097 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature