A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish.

ABSTRACT:

Background

A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa. This current study, therefore, provides an in-depth investigation of this gene family in lower vertebrates including extensive phylogenetic comparison of zebrafish NLRs with orthologs in tetrapods, and analysis of their tissue-specific expression.

Results

Three distinct NLR subfamilies were identified by mining genome databases of various non-mammalian vertebrates; the first subfamily (NLR-A) resembles mammalian NODs, the second (NLR-B) resembles mammalian NALPs, while the third (NLR-C) appears to be unique to teleost fish. In zebrafish, NLR-A an

SUBMITTER: Laing KJ 

PROVIDER: S-EPMC2268669 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature