Single nucleotide polymorphisms (SNPs) in coding regions of canine dopamine- and serotonin-related genes.

ABSTRACT:

Background

Polymorphism in genes of regulating enzymes, transporters and receptors of the neurotransmitters of the central nervous system have been associated with altered behaviour, and single nucleotide polymorphisms (SNPs) represent the most frequent type of genetic variation. The serotonin and dopamine signalling systems have a central influence on different behavioural phenotypes, both of invertebrates and vertebrates, and this study was undertaken in order to explore genetic variation that may be associated with variation in behaviour.

Results

Single nucleotide polymorphisms in canine genes related to behaviour were identified by individually sequencing eight dogs (Canis familiaris) of different breeds. Eighteen genes from the dopamine and the serotonin systems were sc

SUBMITTER: Vage J 

PROVIDER: S-EPMC2268707 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature