Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system.

ABSTRACT:

Background

The mitochondrial oxidative phosphorylation (OXPHOS) is critical for energy (ATP) production in eukaryotic cells. It was previously shown that genes coding for mitochondrial proteins involved in energy production co-express at the RNA level. Because the OXPHOS enzymes are multimeric complexes, we tested the hypothesis that genes coding for components of specific complexes are also co-regulated at the transcriptional level, and share common regulatory elements in their promoters.

Results

We observed for the first time that, not only OXPHOS genes as a group co-express, but there is a co-expression of genes within each of the five OXPHOS enzyme complexes, showing a higher degree of complexity in gene co-regulation. In silico analysis of homologous promoter sequences

SUBMITTER: van Waveren C 

PROVIDER: S-EPMC2268925 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature