Physiology, pathology and relatedness of human tissues from gene expression meta-analysis.

ABSTRACT:

Background

Development and maintenance of the identity of tissues is of central importance for multicellular organisms. Based on gene expression profiles, it is possible to divide genes in housekeeping genes and those whose expression is preferential in one or a few tissues and which provide specialized functions that have a strong effect on the physiology of the whole organism.

Results

We have surveyed the gene expression in 78 normal human tissues integrating publicly available microarray gene expression data. A total amount of 1601 genes were identified as selectively expressed in one or more tissues. The tissue-selective genes covered a wide range of cellular and molecular functions, and could be linked to 361 human diseases with Mendelian inheritance. Based on the gene

SUBMITTER: Greco D 

PROVIDER: S-EPMC2268968 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature