Circadian remodeling of neuronal circuits involved in rhythmic behavior.

ABSTRACT: Clock output pathways are central to convey timing information from the circadian clock to a diversity of physiological systems, ranging from cell-autonomous processes to behavior. While the molecular mechanisms that generate and sustain rhythmicity at the cellular level are well understood, it is unclear how this information is further structured to control specific behavioral outputs. Rhythmic release of pigment dispersing factor (PDF) has been proposed to propagate the time of day information from core pacemaker cells to downstream targets underlying rhythmic locomotor activity. Indeed, such circadian changes in PDF intensity represent the only known mechanism through which the PDF circuit could communicate with its output. Here we describe a novel circadian phenomenon involving extensi

SUBMITTER: Fernandez MP 

PROVIDER: S-EPMC2270325 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature