Analyzing stochastic transcription to elucidate the nucleoid's organization.

ABSTRACT:

Background

The processes of gene transcription, translation, as well as the reactions taking place between gene products, are subject to stochastic fluctuations. These stochastic events are being increasingly examined as it emerges that they can be crucial in the cell's survival. In a previous study we had examined the transcription patterns of two bacterial species (Escherichia coli and Bacillus subtilis) to elucidate the nucleoid's organization. The basic idea is that genes that share transcription patterns, must share some sort of spatial relationship, even if they are not close to each other on the chromosome. We had found that picking any gene at random, its transcription will be correlated with genes at well-defined short - as well as long-range distances, leaving the explana

SUBMITTER: Riva A 

PROVIDER: S-EPMC2270832 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature