Genomic organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wild.

ABSTRACT:

Background

Feline immunodeficiency virus (FIV) naturally infects multiple species of cat and is related to human immunodeficiency virus in humans. FIV infection causes AIDS-like disease and mortality in the domestic cat (Felis catus) and serves as a natural model for HIV infection in humans. In African lions (Panthera leo) and other exotic felid species, disease etiology introduced by FIV infection are less clear, but recent studies indicate that FIV causes moderate to severe CD4 depletion.

Results

In this study, comparative genomic methods are used to evaluate the full proviral genome of two geographically distinct FIV subtypes isolated from free-ranging lions. Genome organization of FIVPle subtype B (9891 bp) from lions in the Serengeti National Park in Tanzania and FIVPle

SUBMITTER: Pecon-Slattery J 

PROVIDER: S-EPMC2270836 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature