Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.

ABSTRACT:

Background

Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures.

Methods and findings

We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation, and to determine the specificity of the PB signature of radiation versus other genotoxic stresses. Neither genotype differences nor the time of PB sampling caused any lessening of the accuracy of PB signatures to predict radiation exposure, but sex difference did influence the accuracy of the prediction of radiation exposure at the lowest level (50 cGy). A PB signature of sepsis was also generated and both the PB signature of radiation and the PB sign

SUBMITTER: Meadows SK 

PROVIDER: S-EPMC2271127 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature