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Novel, orally effective cyanide antidotes.

ABSTRACT: A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.

SUBMITTER: Nagasawa HT

PROVIDER: S-EPMC2274902 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

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Novel, orally effective cyanide antidotes.

Nagasawa Herbert T HT Goon David J W DJ Crankshaw Daune L DL Vince Robert R Patterson Steven E SE

Journal of medicinal chemistry 20071127 26

A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally. ...[more]

PMID: 18038966

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