Novel, orally effective cyanide antidotes.

ABSTRACT: A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.

SUBMITTER: Nagasawa HT 

PROVIDER: S-EPMC2274902 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature