A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

ABSTRACT: We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

SUBMITTER: van Heel DA 

PROVIDER: S-EPMC2274985 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature