A conserved U-rich RNA region implicated in regulation of translation in Plasmodium female gametocytes.

ABSTRACT: Translational repression (TR) plays an important role in post-transcriptional regulation of gene expression and embryonic development in metazoans. TR also regulates the expression of a subset of the cytoplasmic mRNA population during development of fertilized female gametes of the unicellular malaria parasite, Plasmodium spp. which results in the formation of a polar and motile form, the ookinete. We report the conserved and sex-specific regulatory role of either the 3'- or 5'-UTR of a subset of translationally repressed mRNA species as shown by almost complete inhibition of expression of a GFP reporter protein in the female gametocyte. A U-rich, TR-associated element, identified previously in the 3'-UTR of TR-associated transcripts, played an essential role in mediating TR and a similar

SUBMITTER: Braks JA 

PROVIDER: S-EPMC2275103 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature