Assembly and structural analysis of a covalently closed nano-scale DNA cage.

ABSTRACT: The inherent properties of DNA as a stable polymer with unique affinity for partner molecules determined by the specific Watson-Crick base pairing makes it an ideal component in self-assembling structures. This has been exploited for decades in the design of a variety of artificial substrates for investigations of DNA-interacting enzymes. More recently, strategies for synthesis of more complex two-dimensional (2D) and 3D DNA structures have emerged. However, the building of such structures is still in progress and more experiences from different research groups and different fields of expertise are necessary before complex DNA structures can be routinely designed for the use in basal science and/or biotechnology. Here we present the design, construction and structural analysis of a covalen

SUBMITTER: Andersen FF 

PROVIDER: S-EPMC2275108 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature