IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection.

ABSTRACT: Therapeutic vaccination is a potentially powerful strategy to establish immune control and eradicate persistent viral infections. Large and multifunctional antiviral T cell responses are associated with control of viral persistence; however, for reasons that were mostly unclear, current therapeutic vaccination approaches to restore T cell immunity and control viral infection have been ineffective. Herein, we confirmed that neutralization of the immunosuppressive factor interleukin (IL)-10 stimulated T cell responses and improved control of established persistent lymphocytic choriomeningitis virus (LCMV) infection. Importantly, blockade of IL-10 also allowed an otherwise ineffective therapeutic DNA vaccine to further stimulate antiviral immunity, thereby increasing T cell responses and enha

SUBMITTER: Brooks DG 

PROVIDER: S-EPMC2275377 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature